Eleven games cover the upcoming weekend to all but wrap-up pool play, leaving just one game outstanding as Reading face Hemel on 3 October.
The top two in each of the four pools go through to next month's quarter-finals.
We take a look over all the games on offer, and live stats links and available live stream information has been included below.
Two wins from two and the head-to-head tiebreaker with both sides who could potentially catch them means the Kestrels have locked up a semi-final spot with a game to go in Group 1.
Solent will still no doubt be going all-out to gain further momentum ahead of next week's league opener though, with a home tie against the winless London Lions II on the cards for Saturday evening.
That leaves Worthing's trip to Essex as the one remaining fixture in the group, with both teams capable of taking second spot in the group.
5pm - Essex Rebels v Worthing Thunder - LIVE STATS/LIVE STREAM
6pm - Team Solent Kestrels v London Lions II - LIVE STATS/LIVE STREAM
It's still all to play for in Group 2, though Thames Valley can take a big step towards sealing top spot if they can beat Oaklands tomorrow.
After being on the receiving end of a 99-47 thumping by Reading last weekend, a Wolves team featuring lots of academy talent will need to bounce back quickly to avoid a similar fate from last season's league runners up.
Reading will no doubt also have their sights set on a quarter-final place, but they'll have to find a way to beat the Cavs and week 1's Rebound Player of the Week Hakeem Sylla if they're going to make that a reality.
Sunday's other contest sees Hemel looking to bounce back from an opening weekend loss, they host an Oaklands team that they beat 95-63 in their only league meeting last season. Reading face Hemel on 3 October in the final game of the group.
6pm - Thames Valley Cavaliers v Oaklands Wolves - LIVE STATS
5pm - Reading Rockets v Thames Valley Cavaliers - LIVE STATS/LIVE STREAM
5pm - Hemel Storm v Oaklands Wolves - LIVE STATS
A big performance from Hakeem Sylla in @LynchTrophy action 🔥#GameTime pic.twitter.com/5HHGU6o4WK
— NBL (@NBLengland) September 21, 2021
In a similar set up to Group 1, Nottingham Hoods have also all-but claimed top spot with a game to go after wins against Loughborough and Leicester.
The Hoods can continue their rise from the ashes of last season's 2-17 campaign with victory at home to currently winless Charnwood. The D2 invitees will be gunning to secure a top-tier scalp in their final group stage contest though.
Second spot is still up for grabs.
Loughborough recorded their first L Lynch victory on Tuesday evening as they beat nursery team Charnwood 86-62 thanks to 23 points from Harrison Gamble. Coach Jarram's side can make it back-to-back Ws if they can knock off Leicester on Sunday.
Jarram said: “Always a tricky opponent. Like to make the games scrappy, which we must be ready for. We will again be tested with a different style of play and must be locked in for full 40 minutes. Again, great preparation for the regular season.”
3pm - Nottingham Hoods v Charnwood Riders - LIVE STATS
3pm - Loughborough Riders v Leicester Warriors - LIVE STATS/LIVE STREAMS
Team of the Week is 🔙🙌
— NBL (@NBLengland) September 22, 2021
The verdict from @Rebound__ 👇
Both Derby and Newcastle recorded comfortable victories last weekend and will try to do the same again tomorrow to set up a Sunday showdown for top spot.
Derby must first navigate a home tilt with D2 Myerscough, whilst Newcastle are away to Bradford.
Derby Head Coach Matt Shaw said: “This weekend is a great opportunity for us to pick up a good result or two and put ourselves into a quarter-final of a knockout competition and have something to look forward to a bit later in the season, so it’s a big weekend and an important weekend for us."
Should both teams manage to find success on Saturday, the teams will meet in the North East on Sunday evening knowing a place in the quarter-finals is secured.
4pm - Derby Trailblazers v Myerscough - LIVE STATS
5pm - Bradford Dragons v Team Newcastle University - LIVE STATS
4pm - Myerscough v Bradford Dragons - LIVE STATS/LIVE STREAM
5pm - Team Newcastle University v Derby Trailblazers - LIVE STATS
Main image credit - Graham Hodges