CoLA vs Copleston is a highlight in the WEABL as a replay of last season's playoff final, whilst a quartet of games make up the EABL slate, including defending champs Charnwood taking a trip to BMet.
We take a look at all the action below.
BMet City of Birmingham Rockets (1-1) won last time out, beating Derby 72-59 behind 19 points from Reuben Ubogu. They'll look to make it two in a row but it won't be an easy task against defending champs Charnwood College Riders (1-0), who won their opening game of the season back in early October.
Despite last season's #3 seeding and an 8-4 record, its been a slow start to the season for Derby Trailblazers (0-2) after losses against Charnwood and BMet. They'll go hunting for a first win of the season at home to Manchester Magic (1-1), who are fresh off a resounding 122-48 win over SGS College.
In the South, JMA Reading Rockets (1-1) will host Itchen College (0-1) as both teams search for some early season form. Both are coming off a loss heading into the game, with JMA dipping out to Barking and Itchen coming up short against CoLA, but one team will be able to enjoy an uptick after this one.
The league's only other game sees Copleston High School (1-2) looking to get their record back to .500 as they take a trip to City of London Academy - Southwark (1-1), with both teams trying to cut the gap to current South leaders Barking Abbey.
BMet City of Birmingham Rockets vs Charnwood College Riders
Derby Trailblazers vs Manchester Magic
JMA Reading Rockets vs Itchen College
City of London Academy - Southwark vs Copleston High School
All eyes will be on the City of London Academy as unbeaten rivals CoLA (2-0) and Copleston High School (3-0) both put their spotless records on the line in a repeat of last season's playoff final.
The South's other game is a double up from the EABL as JMA Reading Rockets (0-1) and Itchen College (0-1) both try to pick up their first victory of the new campaign. JMA lost heavily against Copleston on the opening day of the season, whilst Itchen went down 58-26 against CoLA, though one team will have a valuable W before the day is out.
In the North, there's another pair of contests as four of the five teams are in action once again.
Last season's conference winners Charnwood College Riders (0-2) have stumbled out of the blocks in their title defence after losses to Manchester and Nottingham. The Sheffield College (1-1) are the next side up for Coach Moodey's team as they try to get themselves up and running.
Milton Keynes 5 Dimensions Breakers Academy (0-1) started life in the WEABL with a loss to Sheffield last week, but they'll have another go at picking up a maiden victory this afternoon as they host the Conference's only unbeaten side, Manchester Mystics (2-0).
City of London Academy - Southwark vs Copleston High School
JMA Reading Rockets vs Itchen College
Charnwood College Riders vs The Sheffield College
Milton Keynes 5 Dimensions Breakers Academy vs Manchester Mystics
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Main image credit - Flo Alalade